The Center for Human Genetics Research at the Massachusetts General Hospital is seeking a highly motivated and versatile post-doctoral fellow to study trinucleotide repeat instability in Huntington¿s disease. The lab employs a variety of genetic, biochemical and cell-based approaches to dissect mechanisms of repeat instability in accurate genetic models of the disease. The position offers the opportunity to work in a stimulating and highly collaborative environment at the forefront of human genetic disease research. Possible projects involve the generation of novel mouse models to test specific hypotheses of repeat instability, and the investigation of repeat instability in induced pluripotent stem (iPS) cells derived from HD patients.

Suitable candidates should hold a Ph.D. in genetics, neurobiology, molecular/cellular biology or related discipline. The successful candidate will have strong background training in molecular biology and mammalian cell culture, the ability to work collaboratively, and excellent oral and written communication skills. Experience with mouse embryonic stem (ES) cells including gene targeting, manipulation of large pieces of genomic DNA using BAC recombineering methodologies, mouse models, and human iPS cells/stem cells is a plus.